2017 -- Conference report inside the country
吳和益、張尹凡、吳怡萱、盧豐華、張智仁、楊宜青、吳晉祥：台灣某族群腎臟囊腫與動脈硬度之相關性研究 台灣家庭醫學醫學會106年度學術研討會會刊 P123-124.
Ho-Yi Wu, Yin-Fan Chang, I-Hsuan Wu, Feng-Hua Lu, Chih-Jen Chang, Yi-Ching Yang, Jin-Shang Wu: The Relationship between Simple Renal Cysts and Arterial Stiffness in a Taiwanese Population
Arterial stiffness is considered as an independent predictor for cardiovascular events and mortality. In clinical practice, brachial and ankle pulse wave velocity (baPWV) is an indicator of arterial stiffness. Although simple renal cysts(SRCs) are thought to be a benign lesions due to their asymptomatic characteristics and remain untreatment usually. No study has been conducted for the association between SRCs and arterial stiffness. Thus, the aim of this study was to investigate the relationship between arterial stiffness and SRCs.
The subjects were recruited from a health examination center of National Cheng Kung University Hospital from October 2006to August 2009 and a total of 6,854subjects were included for the final analysis after excluding subjects met exclusion criteria:positive history of anti-hypertension medications and lipid-lowering agents, or echo image of polycystic kidney disease, medullary sponge kidney, medullary cystic kidney disease, renal ectopia, any cause of hydronephrosis, renal tumor, renal transplantation, or partial nephrectomy. The arterial stiffness was presented by the right baPWV value which was calculated as the distance traveled by the pulse wave divided by the time taken to travel the distance, and it was assessed using an automatically non-invasive vascular screening device (BP-203RPE II; Colin Medical Technology, Komaki, Japan).Sonographic findings of SRCs included(1) absence of internal echoes, (2) posterior enhancement, (3) round/oval shape and (4) sharp, thin posterior walls. SRCs were further classified into different categories based on number (<2 and≥2) and size (<2 cm and ≥2 cm) of the cysts.
Subjects with and without SRCs had right baPWV values of 1522.8± 357.5 cm/sec and 1344.2 ± 268.8 cm/sec, respectively(P<0.001). Based on multiple linear regression analysis, male gender, age ≥65 vs. <65 year, hypertension, diabetes mellitus, total cholesterol to HDL-cholesterol ratio, creatinine, and presence of SRCs(b coefficient:56.43, 95% CI:41.07 ~ 71.79, P<0.001) were positively related to baPWV value after adjustment for other clinical variables. When considering the size of SRCs, both the size <2 cm (b coefficient:50.65, 95% CI:32.69 ~ 68.61, P<0.001) and ≥2 cm(b coefficient:69.23, 95% CI:43.53 ~ 94.94,P<0.001) were associated with increased baPWV value. As for the number of SRCs, cyst number <2 (b coefficient:56.33, 95% CI:40.24~72.43, P<0.001) and ≥2(b coefficient:57.19, 95% CI:15.30~99.09, P<0.01)were also positively associated with baPWV value.
Despite of the SRCs characteristics, the presence of SRCs is associated with an increased of arterial stiffness. Clinically evaluation of arterial stiffness may be considered in subjects with SRCs.