2017 -- Conference report inside the country
沈維真、孫子傑、盧豐華、楊宜青、李芷婷、吳晉祥、張智仁：某台灣族群單純腎臟囊腫與代謝症候群之相關性研究 台灣家庭醫學醫學會106年度學術研討會會刊 P93-94.
Wei-Chen Shen, Zih-Jie Sun, Feng-Hwa Lu, Yi-Ching Yang, Chih-Ting Lee , Jin-Shang Wu, Chih-Jen Chang: The Relationship between Simple Renal Cysts and Metabolic Syndrome in a Taiwanese Population
Simple renal cysts (SRCs) are asymptomatic but they are common findings found by routine health examination. Studies revealed that SRCs are associated with hypertension and diabetes. Metabolic syndrome is known as a cluster of metabolic disorders and is related to increase risk of cardiovascular diseases and diabetes. There are no study on the relationship between SRCs and metabolic syndrome. Thus, the purpose of this study was to investigate the association between the presence of SRCs and metabolic syndrome in a Taiwanese population.
After excluding participants with age <18 years old, anti-hypertensive and anti-diabetes agents use, renal stone, renal cyst with calcification, any cause of hydronephrosis, medullary sponge kidney, medullary cystic kidney disease, renal ectopia, polycystic kidney disease, renal tumor, renal transplantation, and status post nephrectomy, a total of 14,900 subjects underwent health examination and abdominal sonography were enrolled at National Cheng Kung University Hospital from June 2001 to August 2009.Metabolic syndrome is diagnosed if participant fulfills≥ 3 of the following 5 components: (1) fasting blood glucose ≥100 mg/dl ; (2)blood pressure ≥130/85 mmHg; (3) waist circumference ≥90 cm in men or ≥80 cm in women; (4)HDL-C cholesterol <40 mg/dl in men or <50 mg/dl in women and (5) triglycerides ≥150 mg/dl. The diagnosis of SRCs was based on several criteria of abdominal sonography, including: (1) absence of internal echoes, (2) posterior enhancement, (3) round/oval shape and (4) sharp, thin posterior walls. We further categorized SRCs according to their sizes (<3cm and ≥3cm) and numbers (< 2 and ≥ 2).
The prevalence of SRCs was 10.2% (1025/14900), in which 444 subjects (14.0%) had metabolic syndrome and 1081 subjects (9.2%) had not (p < 0.0001).In multiple logistic regression, the presence of SRCs was positively associated with metabolic syndrome (OR= 1.15; 95% CI= 1.02-1.31; p=0.029). In addition, age 40-65years (OR= 2.44; 95% C =2.18-2.74; p< 0.001),age≥ 65 years (OR= 4.59; 95% CI= 3.94-5.34; p < 0.0001), male gender (OR= 1.23; 95% CI= 1.12-1.35; p < 0.001), uric acid level 7-10 mg/dl (OR= 2.37; 95% CI= 2.16-2.60; p < 0.001), uric acid level ≥ 10 mg/dl (OR= 4.91; 95% CI= 3.56-6.79; p < 0.001), smoking(OR= 1.36; 95% CI: 1.19-1.56; p < 0.00) and regular exercise (OR= 0.59; 95% CI= 0.49-0.70; p < 0.0001) were also the correlates of metabolic syndrome. In addition, we found that cyst sizes≥ 3cm (OR=1.37, 95% CI= 1.13-1.66, p=0.002) was also related to an increased risk of metabolic syndrome, but cyst size < 3 cm was not (OR=1.05, 95% CI=0.90-1.22, p=0.566).However, cyst numbers was not significantly associated with metabolic syndrome(number ≥ 2, OR=1.21, 95% CI= 0.92-1.60, p=0.178; number < 2, OR=1.14, 95% CI=1.00-1.31, p=0.056).
Conclusions: SRCs are associated with a higher risk of metabolic syndrome in adults. Cyst size ≥ 3 cm also increases a risk of metabolic syndrome but cyst number seems not.