2017 -- Conference report inside the country
劉建翔、吳晉祥、陳全裕、孫子傑、楊宜青、張智仁、盧豐華：嚼食檳榔與不同血糖狀態之相關性研究 台灣家庭醫學醫 學會106年度學術研討會會刊 P154-155.
Jian-Siang Liou, Jin-Shang Wu, Chuan-Yu Chen, Zih-Jie Sun, Yi-Ching Yang, Chih-Jen Chang, Feng-Hwa Lu: Association of Betel Nut Use with Different Gylcemic Status in a Taiwanese Population
Chewing betel nut has significant detrimental effects on health. Several previous studies had suggested a positive correlation between betel nut chewing and diabetes mellitus. However, the effect of betel nut chewing on various hyperglycemic status including impaired fasting glucose (IFG) and impaired glucose intolerance (IGT) is not explored so far. Therefore, the aim of this study was to investigate the association between betel nut chewing and different hyperglycemic status in Taiwanese population.
After excluding subjects aged <18 years and who currently use medications for diabetes mellitus, 15598 subjects receiving health examination were recruited in this study from June 2001 to August 2009. Betel nut chewing was divided into non-, ex-, and current chewer, respectively. Ex-chewer was defined as those who had regularly chewed betel nut for at least six months, but ceased chewing at least six months prior to the health examination. Current chewer was defined as those who had regularly chewed betel nut for at least the previous six months and was still chewing at the time of the examination. Different hyperglycemic statuses were categorized into normal glucose tolerance, IFG, IGT, and diabetes mellitus according to the following criteria: 1) normal glucose tolerance: fasting plasma glucose (FPG) < 100gm/dl and 2-hr post-load glucose (2-h PG) <140 mg/dl without a history of diabetes; 2) IFG: 100mg/dl ≤ FPG ≤ 125mg/dl and 2-h PG <140 mg/dl without a history of diabetes; 3) IGT: 140mg/dl ≤ 2-h PG ≤ 199mg/dl without a history of diabetes; 4) diabetes mellitus: FPG ≥ 126mg/dl, 2-h PG ≥ 200mg/dl, or a positive history of diabetes, as suggested in 2011 Diagnosis and Classification of Diabetes Mellitus from American Diabetes Association (ADA).
The prevalence of diabetes mellitus was 7%, 10.6%, 12.7% in non, ex-, and current betel nut chewer, respectively. The prevalence of IFG was 6.3 %, 7.4%, 5.4% in non, ex-, and current betel nut chewer, respectively. The prevalence of IGT was 18.5%, 22.1%, 22.5% in non, ex-, and current betel nut chewer, respectively. In multivariate analysis, age ≥ 65 y/r (OR = 7.76, 95% CI: 5.88-10.30), 40 ≤ age < 65 y/r (OR = 3.96, 95% CI: 3.12-5.02), ex- betel nut chewing (OR = 1.51, 95% CI: 1.05-2.17), current betel nut chewing (OR = 1.72, 95% CI: 1.06-2.77), body mass index (BMI) >25 kg/m 2 (OR = 2.39, 95% CI: 2.02-2.83), 23 ≤ BMI ≤ 25 (OR = 1.38, 95% CI: 1.13-1.67), hypertension (OR = 2.03, 95% CI: 1.76-2.35), and serum triglyceride (TG) > 150mg/dl (OR = 2.48, 95% CI: 2.17-2.84) were positively associated with diabetes mellitus. But both ex-, and current betel nut chewing were not associated with IFG (ex: OR =1.35, 95% CI: 0.90-2.03; current: OR =1.01, 95% CI: 0.52-1.94) and IGT (ex: OR =1.22, 95% CI: 0.94-1.59; current: OR =1.20, 95% CI: 0.83-1.75).
Conclusion: Both ex- and current betel nut chewing were associated with increased risk of diabetes mellitus, but not in IFG and IGT.