2017 -- Conference report inside the country
蘇斐琳、李崇豪、張尹凡、吳晉祥、張智仁、盧豐華、楊宜青：某台灣族群之喝茶習慣與膽結石之相關性研究 台灣家庭醫學醫學會106年度學術研討會會刊 P164-165.
Fei-Lin Su, Chung-Hao Li, Yin-Fan Chang , Jin-Shang Wu, Chih-Jen Chang, Feng-Hwa Lu, Yi-Ching Yang: The Association between Tea Drinking Habit and Gallstone in a Taiwanese Population
Gallstone is a common gastrointestinal disorder worldwide. Because of the westernized diet and environment in Taiwan, the prevalence of gallstone becomes increased. Female gender, age, obesity, oral contraceptive use, number of pregnancies, menopause, hepatitis C, chronic kidney disease (CKD),and family history of gallstone are associated with increased risk of gallstone. Sedentary lifestyle, cigarette smoking, and less coffee drinking have been reported as modifiable associated factors. As for the relationship between tea and gallstone, only few studies were conducted and the results were inconsistent. The aim of present study was to investigate the relationship between tea consumption and gallstone, specifically to evaluate the amount of consumption and time of tea consumption by gender. Methods:
The study was carried out between January, 2000 and August, 2009, with total of 19,694 participants for the health examination in National Cheng Kung University Hospital. A total of 14,555 adults were included for final analysis after excluding subjects with cholecystectomy history (n=282) or incomplete data (n=4880).The amount of tea consumption was assessed by questionnaire. The participants were divided into three subgroups: 1) none of tea consumption; 2) tea consumption < 240ml per day; and 3) tea consumption ≥240 ml per day. Furthermore, we defined 120ml for each Chinese traditional teapot as a “ cup ” and the variable“ cup-year ” as multiplying the daily cups by the years of tea consumption. The diagnosis of gallstone was based on the result of an abdominal ultrasound examination after at least 8 hours of fasting. Gallstone was defined by the presence of movable or gravity-dependent intraluminal hyperechoic foci that attenuated ultrasound transmission (acoustic shadow).
Among the 14,555 participants, the average age was49.2 ± 12.7 years old, and 1,040(7.1%) had gallstone. In univariate analysis, the prevalence of gallstone were 7.7%, 5.2%, and 5.8% in subjects with tea consumption of 0, <240ml/day, and ≥240ml/day (p<0.001). After adjusting other clinical variables, the inverse relationship between tea drinking habit and gallstone was significant (adjusted OR= 0.813; 95% CI= 0.690~0.957). In another model, daily consumption of 1~240 ml(OR= 0.749; 95% CI= 0.59~0.95), but not ≥240ml, was associated with reduced risk of gallstone. In addition, 1~19 cup-year group had significantly lower associated risk (OR= 0.678; 95% CI= 0.536~0.859) of gallstone, while ≥19 cup-year group did not. We further analyzed the association between tea consumption with cup-year and gallstone by gender. Subject with tea consumption of1~19 cup-year exhibited a low associated risk of gallstone in both males(OR=0.689; 95% CI=0.512~0.926) and females(OR=0.667; 95% CI=0.450~0.988), while subjects with≥19 cup-year did not.
Appropriate tea drinking was related to a lower associated risk of gallstone in both males and females. Tea drinking with less than 240ml/day or19 cup-year was associated with a decreased risk of gallstone.